피브로넥틴, I형 콜라겐과 비트로넥틴이 조골세포의 이동에 미치는 영향에 대한 연구
분야
의약학 > 의공학
저자
장현석 ( Hyon Seok Jang ) , 임재석 ( Jae Suk Rim ) , 이의석 ( Eui Seok Lee ) , 윤정주 ( Jung Ju Yoon )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2004년, 제1권 제2호, 190~195페이지(총6페이지)
파일형식
2a800009.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Osteoblast migration as well as adhesion is important aspect of bone formation. While the significance of extracellular matrix protein cell interactions are generally appreciated, the specific relationship osteoblast interactions with adhesive extracellular matrix proteins to cell motility is not well defined. We investigated effects of adhesive extracellular proteins on the motility of ROS 17/2.8 cells. Recombinant fibronectin domain 4 (+RGD) and type I collagen promoted cell motility in a dose-dependent manner. Recombinant fibronectin domain 4 - dependent motility was inhibited by anti-1 integrin antibody and GRGDSK peptide. Type I collagen - dependent motility was inhibited anti-2 integrin antibody, demonstrating that the migration supported by these proteins is specifically regulated by their receptors. Surprisingly, vitronectin, a major adhesive protein among serum components, repressed motility. This study demonstrates that diverse mechanisms of osteoblast migration on extracellular matrices exist.
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