자가혈청하에서 FGF-2와 덱사메타손에 의한 골수중간엽줄기세포의 증식과 분화에 대한 효과
분야
의약학 > 의공학
저자
김태호 ( Tae Ho Kim ) , 이선영 ( Sun Young Lee ) , 손영숙 ( Young Sook Son ) , 김석영 ( Suk Young Kim ) , 박의균 ( Eui Kyun Park ) , 김신윤 ( Shin Yoon Kim ) , 유창국 ( Chang Kook You ) , 정필훈 ( Phil Hoon Choung ) , 손민정 ( Min Jung Shon )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2005년, 제2권 제4호, 356~361페이지(총6페이지)
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2a800060.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Previously we have shown that heat-inactivated autologous serum (HAS) has a potential to stimulate proliferation and ostoblastic differentiation of bone marrow stromal cells (BMSCs). In the present study we investigated whether stimulatory effects of HAS on proliferation and osteoblastic differentiation of BMSCs are further potentiated by fibroblast growth factor-2 (FGF-2) and dexamethasone (Dex). As expected, FGF-2 and Dex stimulated proliferation of BMSCs up to 17% at 5 days and 26% at 7 days of culture compared to HAS control. These results suggest that FGF-2 and Dex in the presence of HAS further stimulate proliferation of BMSCs. In order to examine whether BMSCs expanded with FGF-2, Dex and HAS harbor multipotency, the expanded cells were stimulated with either osteogenic or adipogenic cocktails. BMSCs expanded with FGF-2, Dex and HAS for 7 days were able to be differentiated into either osteoblasts or adipocytes. Taken together, these results demonstrate that FGF-2 and Dex in combination with HAS further stimulates proliferation of BMSCs and these expanded cells maintain potentials to be differentiated into either osteoblasts or adipocytes.
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