FGF-2와 덱사메타손이 지방기질세포의 증식 및 분화에 미치는 영향
의약학 > 의공학
김태호 ( Tae Ho Kim ) , 이선영 ( Sun Young Lee ) , 손영숙 ( Young Sook Son ) , 김석영 ( Suk Young Kim ) , 박의균 ( Eui Kyun Park ) , 김신윤 ( Shin Yoon Kim ) , 손민정 ( Min Jung Shon )
조직공학과 재생의학 2005년, 제2권 제4호, 362~367페이지(총6페이지)
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    Adipose tissue derived stromal cells (ATSCs) have been shown to be differentiated into several types of cells including osteoblasts. In the present study we have investigated the effects of fibroblast growth factor-2 (FGF- 2) and dexamethasone (Dex) on the proliferation and osteoblastic differentiation of ATSCs. A combination of FGF- 2 and Dex compared to untreated control stimulated proliferation of ATSCs up to 45% and 25% at day 5 and 7, respectively. Compared to FGF-2 alone, FGF-2 plus Dex further augmented proliferation of ATSCs by 15% (day 5) and 5% (day 7). In response to osteogenic stimulation, ATSCs expanded with FGF-2/Dex for 7 days were able to be differentiated into osteoblasts as revealed by increased calcium precipitation, and increased expression of osteocalcin, alkaline phosphatase and Runx2. Taken together, these results demonstrate that FGF-2 in combination with Dex stimulates proliferation of ATSCs and FGF-2/Dex-expanded ATSCs maintain a potential to be differentiated into osteoblasts.
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