Effect of BDNF on the Neural Differatiation of Rat Bone Marrow Stromal Cells
의약학 > 의공학
( Kyung Jin Lee ) , ( Chang Hyun Jeong ) , ( Ji Hyun Oh ) , ( Seok Gu Kang ) , ( Jung Yeon Lim ) , ( Seong Muk Kim ) , ( Sin Soo Jeun ) , ( Sang In Park, )
조직공학과 재생의학 2005년, 제2권 제4호, 378~382페이지(총5페이지)
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    Bone marrow stromal cells (BMSCs) exhibit multiple traits of a stem cell population, and they can expand many times in vitro and be induced to differentiate into multiple cell types. Several neurotrophins mediate the survival, differentiation, growth and apoptosis of neuron by binding to the neurotrophin factor receptor. Brain derived neurotrophic factor (BDNF) is known to have important functions for in neuronal survival in the nervous system, it enhances stem cells` ablilty to differentiate into neural cells and it promotes plasticity in vitro and in vivo. In this study, we investigated the effect of BDNF on the neural differentiation of rat BMSCs. The effect of BDNF on the neural differentiation of rat BMSCs was examined via imunocytofluorescence, western blotting and FACS analysis of specific neural markers in the neural induction condition and the BDNF-treated neural induction condition. According to our results, the expression of neural markers was higher in the BDNF treated neural induction condition compared to in the neural induction condition. Theses results show that BDNF promotes the neural differentiation of rat BMSCs.
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