A biodegradable and porous poly(L-lactide-co-glycolide) (PLGA) scaffold has been proposed for the application of cytokine carrier and tissue engineered spinal cord. The brain-derived neurotrophic factor (BDNF) loaded PLGA scaffolds was prepared by ice-particle leaching method to control release from porous polymer scaffolds. The release amount of BDNF from BDNF loaded PLGA scaffold was observed about 4 weeks period in vitro at phosphate buffered saline (PBS, pH 7.4) at 37oC and analyzed by enzyme-linked immunosorbent assay (ELISA). Prepared PLGA scaffold had uniform porosity and good interconnection between pores. Release amount of BDNF increased with increasing BDNF content. These results suggest that the released BDNF from BDNF loaded PLGA scaffold such as conduit type can be very useful for the nerve regeneration in the neural tissue engineering area.