BDNF를 함유한 PLGA 지지체의 제조 및 특성 평가
분야
의약학 > 의공학
저자
이해방 ( Hai Bang Lee ) , 강길선 ( Gil Son Khang ) , 김선경 ( Sun Kyung Kim ) , 김순희 ( Soon Hee Kim ) , 김문석 ( Moon Suk Kim ) , 이혜란 ( Hye Ran Lee ) , 조미희 ( Mi Hee Cho )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2005년, 제2권 제4호, 388~391페이지(총4페이지)
파일형식
2a800065.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    A biodegradable and porous poly(L-lactide-co-glycolide) (PLGA) scaffold has been proposed for the application of cytokine carrier and tissue engineered spinal cord. The brain-derived neurotrophic factor (BDNF) loaded PLGA scaffolds was prepared by ice-particle leaching method to control release from porous polymer scaffolds. The release amount of BDNF from BDNF loaded PLGA scaffold was observed about 4 weeks period in vitro at phosphate buffered saline (PBS, pH 7.4) at 37oC and analyzed by enzyme-linked immunosorbent assay (ELISA). Prepared PLGA scaffold had uniform porosity and good interconnection between pores. Release amount of BDNF increased with increasing BDNF content. These results suggest that the released BDNF from BDNF loaded PLGA scaffold such as conduit type can be very useful for the nerve regeneration in the neural tissue engineering area.
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