젤방사성형법에 의한 혈관용 스캐폴드의 제조 및 특성
분야
의약학 > 의공학
저자
김영하 ( Young Ha Kim ) , 김상헌 ( Sang Heon Kim ) , 김수현 ( Soo Hyun Kim ) , 한성식 ( Sung Sik Han ) , 권재현 ( Jae Hyun Kwon ) , 박인수 ( In Su Park ) , 고영건 ( Young Gun Ko ) , 정민섭 ( Min Sub Jung ) , 정은나 ( Eun Na Chung )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2006년, 제3권 제1호, 39~45페이지(총7페이지)
파일형식
2a800077.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    We developed a biodegradable porous scaffold fabricated by a gel spinning method using a biodegradable and elastic polymer, poly(L-lactide-co-ε-caprolactone) (PLCL) (50:50) for vascular grafts application. To characterize the scaffold, we tested fiber thickness, SEM, cell seeding efficiency, tensile properties, and elasticity. In seeding test, we used bone marrow mononuclear cells isolated from rabbit. Furthermore, we examined tissue ingrowth activities for the scaffolds implanted in nude mice. The fiber thickness of the gel-spun scaffolds increased as the concentration of polymer solution increased. In mechanical properties such as tensile strength and elasticity, the gel-spun scaffolds were superior to scaffolds fabricated by a extrusion technique. In addition, the cell seeding efficiency of the scaffolds was higher than that of other scaffolds fabricated by compared methods. In implantation experiments, the scaffolds showed a good tissue ingrowth through open spaces between micro fibers. In conclusion, gel-spun tubular scaffolds can be a good candidate as scaffolds for cardiovascular tissue engineering.
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