배아줄기세포 이식과 사이토카인 투여의 복합치료술을 적용한 심근경색 치료
분야
의약학 > 의공학
저자
김병수 ( Byung Soo Kim ) , 최차용 ( Cha Yong Choi ) , 김일권 ( Il Kwon Kim ) , 곽소정 ( So Jung Gwak ) , 조승우 ( Seung Woo Cho ) , 유경종 ( Kyung Jong Yoo )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2006년, 제3권 제1호, 52~57페이지(총6페이지)
파일형식
2a800079.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    In the present study, we tested the hypothesis that granulocyte colony-stimulating factor (G-CSF) administration would enhance the efficacy of cellular cardiomyoplasty with embryonic stem (ES) cells in infarcted myocardium. Three weeks after myocardial infarction by cryoinjury, Sprague-Dawley rats were randomized to receive either an injection of medium, ES cell transplantation, G-CSF administration, or a combination of G-CSF administration and ES cell transplantation. Prior to transplantation, ES cells were induced to differentiate into cardiomyocytes. Eight weeks after treatment, the cardiac tissue formation, neovascularization, and apoptotic activity in the infarct regions were evaluated by histology and immunohistochemistry. The left ventricular (LV) dimensions and function of the treated heart were evaluated by echocardiography. Transplanted ES cells survived and participated in the myocardial regeneration in the infarcted heart. A combination of G-CSF treatment and ES cell transplantation significantly promoted angiogenesis and reduced the infarct area and cell apoptosis in the infarcted myocardium compared with ES cell transplantation alone. The combination therapy also attenuated LV dilation, ascompared with ES cell transplantation alone. The present study demonstrates that G-CSF treatment can enhance the efficacy of cellular cardiomyoplasty by ES cell transplantation to treat myocardial infarction.
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