Safety and Physiochemical Properties of Novel Sustained Release Collagen based Drug Delivery System (COL-DDS) in Rabbit Eye

분야: 의약학 > 의공학
저자: ( Dong Myong Kim )
발행기관: 한국조직공학·재생의학회
간행물정보: 조직공학과 재생의학 2006년, 제3권 제2호, 142~150페이지(총9페이지)
파일형식: 2a800093.pdf [무료 PDF 뷰어 다운로드]
※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
구매가격: 4,500원
적립금: 135원 (구매자료 3% 적립)

이메일 발송 스크랩 하기

자료 다운로드 네이버 로그인

연관 논문

Original Article : Inhibition of the IL-1β-induced Expression of Matrix Metalloproteinases by Controlled Release of IL-1 Receptor Antagonist Using Injectable and Thermo-reversible Gels in Human Osteoarthritis Chondrocytes

1P-76 : Novel Cyclodextrin Functionalized Agarose Hydrogel for Effective Drug Delivery System

원보 : 록소프로펜 플라스터의 제제설계 및 평가 ( Original articles : Formulation and Evaluation of Loxoprofen Plasters )

원보 / 프로스타글란딘 E1 요도좌제의 제조 및 평가 ( Preparation and Evaluation of PGE1 Transurethral Suppositories )

1P-463 : Simple fabrication of silver hybridized porous chitosan-based patch for transdermal drug-delivery system

영문초록

The aim of this study was to examine the safety and physiochemical properties of a new biodegradable and biocompatible collagen based drug delivery system(COL-DDS) implanted into the anterior chamber in a rabbit eye. The physiochemical and ultra-structural differences of COL-DDS were evaluated with and without crosslinking with carboxymethylcellulose(CMC). The in vitro and in vivo assays of the collagen released and the residual collagen content revealed an expected inverse relationship between the collagen release rate and the swelling ratio of the COL-DDS, which might be exploited for the controlled presentation and release of carriers. Fifty New Zealand albino rabbits(20 eyes) undergoing phacoemulsification were divided into two groups receiving normal saline eye drops(group A) and a COL-DDS implanted subconjunctivally into the anterior chamber(group B). Collagen/CMC crosslinked COL-DDS showed a significantly higher level of reduction in the swelling ratios compared with the non crosslinked COL-DDS(two-factor ANOVA, p<0.0001). Crosslinking as well as the collagen content had a significant effect on the volume changes(two-factor ANOVA, p=0.001). The mean aqueous humor collagen level in groups A and B was 0.0121 ?g/ml and 25.964 ?g/ml, respectively. Collagen was still detectable in the aqueous humor after the DDS had completely dissolved at 12 weeks in group B. The slit-lamp biomicroscopy revealed no inflammatory signs in the anterior chamber. The conjunctiva, cornea, iris, ciliary body and retina remained intact, and no significant toxic reactions were observed. The implantation of a COL-DDS into the anterior chamber of the experimental animals maintained a similar collagen level in the aqueous humor for a relatively long period of time. This highlights the potential for the prevention of anterior chamber disease with minimal toxic and side effects. Therefore, a long acting DDS requiring only a weekly subcutaneous administration appears to be useful in a clinical setting.

#collagen based drug delivery system(COL-DDS)# carboxymethylcellulose(CMC)# swelling ratio # cross link # anterior chamber

약물 전달 시스템에서 주요 연구 분야에 대한 특허 분석

[반응공학] Nano diagnosis technology(영문)

[전략관리] 3M 쓰리엠 핵심역량(영문)

영문 HANNIBAL 한니발 영화 대사

[공항운영론] Airport Security and Facilitation

[공항운영론] Airport Security and Facilitation(공항 보안과 조성)(영문)

[PBL] 전신부종과 호흡곤란을 호소한 젊은 여자

Making Index implementation by red-black-tree Algorithms

영문 트루 라이즈 TrueLies 영화 대사

오늘 본 자료