흰쥐의 척수손상 모델에 제대혈유래 중간엽줄기세포의 이식부위에 대한 행동학적 움직임에 관한 연구
분야
의약학 > 의공학
저자
정창현 ( Chang Hyun Jeong ) , 박상인 ( Sang In Park ) , 임정연 ( Jung Yeon Lim ) , 김성묵 ( Seong Muk Kim ) , 전진애 ( Jin Ae Jun ) , 전신수 ( Sin Soo Jeun )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2006년, 제3권 제2호, 169~174페이지(총6페이지)
파일형식
2a800096.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Multipotential mesenchyman stem cells (MSCs) can differentiate into the neural cells in vitro and they have been shown to promote neuronal survival and functional recovery after implantation into various neurological disease models such as cerebral infarction, brain trauma, spinal cord injury and Parkinson disease. In this study, we examined the effect of human umbilical cord blood-derived MSCs (hUCB-MSCs) on spinal cord injury (SCI) model saccording to the transplantation site through functional recovery test, cavity volume and migration to injury site. The spinal cord was injured by contusion using a weight-drop at the level of T9. The seven days after injury, the hUCB-MSCs (5 × 105 cells/?l) labeled with PKH26 were transplanted into rostral, caudal, epicenter sites of SCI. The results were: (1) a behavioral test (BBB score) showed a significant functional improvement in groups that had transplanted MSCs into rostral site as compared to transplanted group into caudal or epicenter site, (2) the cavity volume was the smallest in MSCs transplanted groups into rostral site, and (3) PKH26-labeled cells observed around the injury site were a greater in MSCs transplanted group into rostral site than other groups. Taken together, rostral site would be a valuable when performing stem cell transplantation therapy for treating SCI.
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