에리스로마이신을 함유한 폴리비닐알콜용액의 젤화 거동 평가

분야: 의약학 > 의공학
저자: 이해방 ( Hai Bang Lee ) , 강길선 ( Gil Son Khang ) , 이정원 ( Jung Won Lee ) , 김문석 ( Moon Suk Kim ) , 양성윤 ( Sung Yun Yang ) , 김유한 ( Yu Han Kim )
발행기관: 한국조직공학·재생의학회
간행물정보: 조직공학과 재생의학 2006년, 제3권 제3호, 279~285페이지(총7페이지)
파일형식: 2a800102.pdf [무료 PDF 뷰어 다운로드]
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영문초록

PVA hydrogel, which prepared by freezing-thawing or irradiation crosslinking, is widely utilized in biomedical field as biocompatible hydrogels. In this study, we examined the gelation for PVA solution containing erythromycin( EM) as a model crystalline drug. EM loaded PVA solution was prepared in the presence of various additives such as ethyl carbitol, polyethylene glycol, glycerol, and Tween 80. No gelation of these solutions observed at room temperature. However, gelation due to crystallization was occurred by freezing-thawing method with dependence of additives. This result indicated that gelation of EM loaded PVA could be controlled by additives. To examine the formation of intermolecular hydrogen bonding between PVA and EM, EM loaded PVA solution with and without various additives was analyzed by using X-ray diffraction(XRD) and differential scanning calorimetry( DSC). The characteristic peak assignable to PVA or EM observed, but the peaks changed or disappeared in the presence of various additives. In addition, the crystallinity of EM loaded PVA solution decreased in the presence of various additives. In conclusion, we can control the gelation of EM loaded PVA solution through the addition of additives.

#PVA # erythromycin # gelation # crystalline drug # additives

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