인공 장애물에 의한 심실세동의 동역학적 변화의 광학적 지도 분석
분야
의약학 > 의공학
저자
김성순 ( Sung Soon Kim ) , 황기철 ( Ki Chul Hwang ) , 구본권 ( Bon Kwon Koo ) , 이문형 ( Moon Hyoung Lee ) , 김일권 ( Il Kwon Kim ) , 정보영 ( Bo Young Joung ) , 서정철 ( Zheng Zhe Xu )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2006년, 제3권 제3호, 286~294페이지(총9페이지)
파일형식
2a800103.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    The effects of artificial obstacles on the dynamics of ventricular fibrillation have been extensively investigated with an electrical mapping system. This study was performed to assess the influence of transmural obstacles on the dynamics of wavefronts and to determine whether obstacles can convert ventricular fibrillation to ventricular tachycardia by stabilizing wavefronts in fibrillating right ventricular tissues of pigs using an optical mapping system. The right ventricles of pigs(n=15) were excised and placed in a tissue perfusion system with the epicardium facing up. A hole of increasing size from 2 mm to 8 mm in diameter was created using a skin biopsy punch. Then, the other 8mm sized hole was made just beside the first hole. The changes of wavefront dynamics and the cycle length of optical action potential waves were investigated. In 14 among 20 obstacles of ten tissues, transient attachment of electrical activities along the rim of obstacles and transient rotation of wavefronts were observed. During baseline ventricular fibrillation, fibrillation cycle length was 118.5±24.7 msec and this was increased to 135.4±30.2 msec after 8mm hole, and to 159.4±47.7 msec after 2 holes(p=0.01). There was a positive correlation between the obstacle size and cycle length(r=0.43, p=0.007). In three tissues, conversion to ventricular tachycardia from ventricular fibrillation was observed after creation of two holes. Obstacles of proper size had anti-fibrillatory effects in tissues with ventricular fibrillation and this phenomenon was partly explained by the temporary attachment of wavefronts to the obstacles.
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