Elevated Levels of Inflammatory and Vasoactive Factors in the Culprit Coronary Artery of Acute Myocardial Infarction
의약학 > 의공학
( Dong Hoon Choi ) , ( Yang Soo Jang ) , ( Sung Ha Park ) , ( Seung Yun Cho ) , ( Won Heum Shim ) , ( Nam Sik Chung ) , ( Young Guk Ko ) , ( Ki Chul Hwang ) , ( Bo Young Joung ) , ( Jae Hun Jung ) , ( Eui Young Choi )
조직공학과 재생의학 2006년, 제3권 제3호, 313~318페이지(총6페이지)
2a800107.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    135원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    Distal embolization of the thrombus and plaque debris, as well as the release of inflammatory and vasoactive factors are suggested as important factors that may jeopardize successful myocardial reperfusion during primary coronary intervention. However, there are currently few clinical data on the presence and the role of such factors. We performed in 18 acute myocardial infaction patients primary percutaneous coronary intervention(PCI) with the distal protection device of distal occlusive balloon type, PercuSurge GuideWire system. We collected blood samples from the femoral artery before PCI and from culprit coronary artery using Export aspiration catheter after predilation while inflating the distal protection balloon and after completing PCI with deflation of the distal protection balloon. We determined concentrations of C-reactive protein, soluble CD40 ligand, IL-6, serotonin, tissue factor, and factor VIIa inblood samples. The concentrations of soluble CD40 ligand(2.84±3.74 vs 0.98±0.63 ng/mL, p= 0.004), IL-6(33.67±32.63 vs 17.08±21.41 pg/mL, p<0.001), serotonin(2.05±0.76 vs 0.92±0.60 ng/mL, p<0.001), tissue factor (257.17±84.34 vs 154.60±87.99 pg/mL, p<0.001) and factor VIIa(34.30±27.30 vs 24.19±28.00 ng/mL, p=0.016) were significantly higher in the culprit coronary artery after the first predilation than those in the peripheral blood before PCI. However, the CRP concentrations in the samples from the culprit coronary artery and the femoral artery did not differ significantly(4.15±3.19 vs 4.60±3.68 mg/L, p=0.056). The blood samples from coronary artery after multiple aspirations showed reduced concentrations of soluble CD40 ligand(2.84±3.74 to 1.64±1.96 ng/mL, p=0.030), IL-6(33.67±32.63 to 22.44±21.87 ng/mL, p=0.010), serotonin(2.05±0.76 to 1.29±0.82 ng/mL, p<0.001), tissue factor(257.17±84.34 to 198.45±95.14 ng/mL, p=0.001) and factor VIIa(34.30±27.30 to 27.65±27.24 ng/mL, p=0.001) compared to those in the coronary aspirates obtained after first balloon dilation of the culprit lesions. We found increased levels of soluble inflammatory and vasoactive factors such as soluble CD40 ligand, IL-6, serotonin, tissue factor and factor VII in the aspirate from the culprit coronary artery compared to those in peripheral blood. The aspiration of blood from culprit lesion during PCI resulted in significantly reduced concentrations of inflammatory and vasoactive markers.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.