Alginate Gel Decreases Chondroitin Sulfate Proteoglycan Immunoreactivity Following Spinal Cord Injury: Preliminary Study
분야
의약학 > 의공학
저자
( Hong Tae Kim ) , ( Jong Ki Kim ) , ( Gi Hwan Choi ) , ( Yeon Hee Youn ) , ( Duk Youn Kim ) , ( Ho Sang Son )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2006년, 제3권 제4호, 472~477페이지(총6페이지)
파일형식
2a800128.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    4,500원
    적립금
    135원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    영문초록
    In order to understand the potential role of alginate bridge in the spinal cord regeneration followed by contusion injury, chondroitin sulfate proteoglycans immunoreactivity(CSPG-IR) was assessed at 7-days post-contusion injury sites with or without alginate gel(ALGEL) bridge using immunocytochemistry with CSPG antibody conjugated to FITC and carbazole assay of tissue extracted CSPG. Fluorescence intensity, representing a degree of CSPG-IR, from post-contusion injury group with alginate gel bridge decreased significantly compared to post-contusion injury group without alginate group. In addition carbazole assay demonstrated that CSPG expression at 7 days post-contusion injury with alginate gel group decreased by 11.2~35.8 %. Selected sections along axonal direction, stained with myelin, of the lesion site showed clearly regenerated spinal tissues in the gapped lesion with alginate gel 3 weeks post-contusion injury. In conclusion, this preliminary study may suggest that a decreased expression of CSPG, known as an inhibitor of spinal cord regeneration, may be potential effects of the alginate bridge at spinal cord contusion injury site.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.