Alginate Gel Decreases Chondroitin Sulfate Proteoglycan Immunoreactivity Following Spinal Cord Injury: Preliminary Study

분야: 의약학 > 의공학
저자: ( Hong Tae Kim ) , ( Jong Ki Kim ) , ( Gi Hwan Choi ) , ( Yeon Hee Youn ) , ( Duk Youn Kim ) , ( Ho Sang Son )
발행기관: 한국조직공학·재생의학회
간행물정보: 조직공학과 재생의학 2006년, 제3권 제4호, 472~477페이지(총6페이지)
파일형식: 2a800128.pdf [무료 PDF 뷰어 다운로드]
※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
구매가격: 4,500원
적립금: 135원 (구매자료 3% 적립)

이메일 발송 스크랩 하기

자료 다운로드 네이버 로그인

연관 논문

VTA GABA Modulates the Motivational Drive for the Reward on the Neuropathic Pain Following Spinal Cord Injury in Rats

Isoflurane Preconditioning Induces Neuroprotection by Up-Regulation of TREK1 in a Rat Model of Spinal Cord Ischemic Injury

Articles : GM-CSF reduces expression of chondroitin sulfate proteoglycan (CSPG) core proteins in TGF-β-treated primary astrocytes

원저 : 흰쥐에서 척수 손상후 반응성 별아교세포에서의 CNTF 발현 증가 ( Increased CNTF Expression in the Reactive Astrocyte Following Spinal Cord Injury in Rats )

원저 : 척수손상에 의한 운동유발전위와 척수유발전위의 변화 ( CHANGES OF MOTOR EVOKED POTENTIALS AND SPINAL CORD EVOKED POTENTIALS FOLLOWING SPINAL CORD INJURY IN RATS )

영문초록

In order to understand the potential role of alginate bridge in the spinal cord regeneration followed by contusion injury, chondroitin sulfate proteoglycans immunoreactivity(CSPG-IR) was assessed at 7-days post-contusion injury sites with or without alginate gel(ALGEL) bridge using immunocytochemistry with CSPG antibody conjugated to FITC and carbazole assay of tissue extracted CSPG. Fluorescence intensity, representing a degree of CSPG-IR, from post-contusion injury group with alginate gel bridge decreased significantly compared to post-contusion injury group without alginate group. In addition carbazole assay demonstrated that CSPG expression at 7 days post-contusion injury with alginate gel group decreased by 11.2~35.8 %. Selected sections along axonal direction, stained with myelin, of the lesion site showed clearly regenerated spinal tissues in the gapped lesion with alginate gel 3 weeks post-contusion injury. In conclusion, this preliminary study may suggest that a decreased expression of CSPG, known as an inhibitor of spinal cord regeneration, may be potential effects of the alginate bridge at spinal cord contusion injury site.

#Spinal cord regeneration # chondroitin sulfate proteoglycan # alginate gel # neuronal growth inhibitor

추천자료

의학용어 약어정리

뇌졸중의 전문적 재활치료에 대하여

치아의 구조와 치주질환, 치료방법에 대하여(영문)

[PBL] 좌식 생활 질환

[병리학 논문분석] PDL cell과 LPS와 nicotine 처리했을때의 VEGF 발현에 관한 연구

증후군의 정의 및 종류, 원인, 증상, 대책, 최근 연구동향을 통한 나의 의견 정리

[생명] 발생학 노트 정리

수학과 생물학의 만남(영문)

[영문] 수학과 생물학의 만남

[식품저장학] 식품 저장 시 부패 미생물의 생육 저해방법에 대한 최근 동향