연구논문 : 슈반세포가 골수간엽줄기세포의 분화에 미치는 영향
분야
의약학 > 의공학
저자
김초민 ( Cho Min Kim ) , 김수미 ( Su Mi Kim ) , 김순희 ( Soon Hee Kim ) , 이일우 ( Il Woo Lee ) , 김문석 ( Moon Suk Kim ) , 이종문 ( John M. Rhee ) , 강길선 ( Gilson Khang ) , 이해방 ( Hai Bang Lee )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2007년, 제4권 제1호, 60~66페이지(총7페이지)
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2a800145.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    We have investigated differentiation of bone marrow stromal cells(BMSCs) through co-culture system with Schwann cells(SCs). Expression of the S-100, Schwann cell markers, was determined by immunocytochemical staining and reverse transcriptase polymer chain reaction(RT-PCR). The morphology and growth in terms of differentiated BMSC was observed by invert microscope. Following co-culture time with SCs, BMSCs underwent morphological changes similar to those of cultured SCs and stained positively for S-100 protein as well as high proliferation aspect were detected. Electrophoresis analysis revealed that the levels of S-100 on BMSC co-cultured with SCs related with other group maintained up to 21 days. These findings support the assertion that BMSCs can be differentiated into cells that are Schwann cell-like in terms of phenotype using Schwann cell only.
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