연구논문 : 마우스 두개골 결손 모델에서 지방줄기세포와 BMP-2의 골 재생 효능 비교
분야
의약학 > 의공학
저자
강선웅 ( Sun Woong Kang ) , 나완근 ( Wan Geun La ) , 강진묵 ( Jin Muk Kang ) , 이종호 ( Jong Ho Lee ) , 박정호 ( Jung Ho Park ) , 김병수 ( Byung Soo Kim )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2007년, 제4권 제3호, 382~387페이지(총6페이지)
파일형식
2a800172.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    In vivo bone regeneration can be achieved either by transplantation of osteogenic cells differentiated from adipose-derived stem cells (ADSCs) or by delivery of exogenous bone morphogenetic protein-2 (BMP-2). In this study, we compared the osteogenic potential between ADSCs and BMP-2 in a mouse calvarial defect model. Critical- sized circular calvarial defects were made in nude mice. The mice were randomized into 4 groups (n=6 per group) that were treated with either 1) fibrin glue alone, 2) fibrin glue with BMP-2, 3) fibrin glue with undifferentiated ADSCs, or 4) fibrin glue with osteogenically differentiated ADSCs. Specimens were harvested at 8 weeks after treatment and evaluated radiographically and histologically. Differentiation of human ADSCs prior to transplantation did not affect bone regeneration. Transplantation of ADSCs was not superior to BMP-2 delivery for in vivo bone formation in a mouse calvarial defect model.
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