일반총설 : 치조골 재생용 인공재료의 요구조건
분야
의약학 > 의공학
저자
최정원 ( Jeong Won Choi ) , 신현재 ( Hyun Jae Shin )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2007년, 제4권 제4호, 478~483페이지(총6페이지)
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2a800179.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Surgical placement of dental implants may be difficult, if at all possible, due to the alveolar ridge resorption. Before implant placement or simultaneously at the time of implant surgery, thus, it is necessary to augment alveolar bone. Benefits from the osteogenic potential of autograft bone treatment are restricted due to limited donor tissue resources and morbidity, besides the possibility that bone modeling may result in undesirable alterations in tissue volume and geometry. Recently, allogeneic or xenogeneic bone derivatives, and ceramic and polymeric bone substitutes (potentially osteoconductive) have been suggested for the reconstruction of bone. Some requirements for such an artificial bone substitute materials are considered in this review. Early resorption of an implanted material should not interfere with bone formation and late resorption should not compromise bone maintenance. It is critical that any implanted biomaterial does not impair bone formation by obstructing the wound space, negating or delaying the native osteogenic potential of the site. Nor should its long-term residence injure mechanical properties of bone including load-bearing and dental implant osseointegration. Osteoconduction needs a property of a biomaterial that promotes ingrowth of bone into a defect from osteogenic tissue sources and is usually attributed to the geometry, porosity and bioreactivity of the material. The graft materials also have to get enough strength to overcome wound contraction during healing period. For bone regeneration in challenging area, effective osteoinductive or osteogenic materials should be required. Recent advances in tissue engineering may offer several solutions. Some signaling molecules such as cytokines and growth factors are introduced to graft material for osteoinduction. Bone matrixes and osteoblasts derived from periosteal cells and bone marrow cells cultivated by tissue engineering on a scaffold have recently been used as osteogenic material for alveolar bone regeneration.
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