유화동결건조법으로 제조된 HA/PLGA 지지체를 이용한 연골 재생
분야
의약학 > 의공학
저자
정수현 ( Su Hyun Jung ) , 장지욱 ( Ji Wook Jang ) , 김순희 ( Soon Hee Kim ) , 홍현혜 ( Hyun Hye Hong ) , 오아영 ( A Young Oh ) , 이종문 ( John M. Rhee ) , 강영선 ( Young Sun Kang ) , 강길선 ( Gil Son Khang )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2008년, 제5권 제4호, 643~649페이지(총7페이지)
파일형식
2a800261.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    4,500원
    적립금
    135원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    영문초록
    Adult articular cartilage tissue has poor capability of self-repair. Therefore, a variety of tissue engineering approaches are motivated by the clinical need for articular repair. PLGA and hyaluronic acid(HA) has been widely used as biocompatible scaffolds materials to regenerate tissue. HA loaded PLGA scaffolds were prepared by a emulsion freeze-drying method. The chondrocytes were seeded on the HA-PLGA scaffolds and measured by MTT assay. Morphological observation, histology, biological assay for collagen and sGAG, and PCR were performed. In MTT assay result, scaffolds containing HA were higher cell viability then only PLGA scaffolds. Although collagen, sGAG, mRNA and collagen type II were greater than HA-PLGA scaffolds and collagen type I was less than HA/ PLGA scaffolds. When we cultured cartilage cell of rabbit in vitro, we observed better to keep the characteristic of cartilage cell in the HA-PLGA scaffolds than that PLGA scaffolds. This study suggests that HA/PLGA scaffold may serve as a potential cell delivery vehicle and a structural basis for in vitro tissue engineered articular cartilage.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.