5-FU 하이드로겔을 이용한 생체외 피부투과거동
분야
의약학 > 의공학
저자
안식일 ( Sik Il Ahn ) , 박상욱 ( Sang Wook Park ) , 박종학 ( Jong Hak Park ) , 이준희 ( Jun Hee Lee ) , 김윤태 ( Yun Tae Kim ) , 김대성 ( Dae Sung Kim ) , 김원 ( Won Kim ) , 이한구 ( Han Koo Lee ) , 신형식 ( Hyung Shik Shin ) , 이종문 ( John M Rhee ) , 강길선 ( Gil Son Khang )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2008년, 제5권 제4호, 660~665페이지(총6페이지)
파일형식
2a800263.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    5-Fluorouracil(5-FU) has been widely used to treat cancer as types of iv and oral adminstration. However, it induces many side effects and has short half-life time of 10-20 minutes. Furthermore, it has low bioavailability of 20 % due to the hepatic first pass effect. Therefore, we developed novel TDDS using hydrogel and microneedle system. 5, 8 and 10% w/v of Carbopol 940NF was added in hydrogel containing 5-FU to improve permeability. Viscosity of hydrogel increased with increase of Carbopol contents. We applied these novel DDS to hairless mice skin treated and untreated with microneedle system and evaluated drug permeability into skin. The hydrogel containing 8% w/v Carbopol showed best permeability among three groups. We concluded viscosity of drug acts important factor in permeability into skin and bioavailability could be improved through our novel TDDS.
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