소동물에서 복강내 장기의식실험을 위한 이상적인 마취약 투여경로에 대한 제안
분야
의약학 > 의공학
저자
김준예 ( Joon Ye Kim ) , 이정익 ( Jeong Ik Lee ) , 방우휘 ( Yu Hui Fang ) , 정진호 ( Jin Ho Jeong ) , 김유선 ( Yu Seun Kim )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2008년, 제5권 제4호, 829~834페이지(총6페이지)
파일형식
2a800283.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Intraperitoneal(lP) administration of anesthesia is commonly used for laboratory animal experiment including islet isolation using abdominal organ. However, the direct effects of anesthetics towards organs of abdom?inal cavity such as pancreas have been neglected. To evaluate the direct effects of anesthetic agents to the pancreas when isolating pancreatic islets, we compared the islet function and recovery yield from the rats that were anesthe?tized using IP and intramuscular(IM) routes. Lewis was anesthetized using the combination of zoletil and xyla?zine(Z/X). These drugs were injected through 1M or IP route. To shot 1M drugs, we have invented a specially designed restrainer. Glucose challenging test was performed with each group of prepared islets within 30 minutes after isolation procedure. Yield of isolated islets by 1M route was significantly improved(1M: 1136±226 ea, IP: 511±154 ea). Function of fresh islet with 1M route was better kept than oflP, which was expressed by stimulation index. For rodent islet isolation, 1M route for anesthesia is simpler and safe way compared with IP route. It is sug?gested that 1M route is versatile in laboratory animal experiments.
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