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분야
의약학 > 의공학
저자
박세일 ( Se Il Park ) , 문영미 ( Young Mi Moon ) , 김산옥 ( San Ok Kim ) , 정규식 ( Kyu Shik Jeon ) , 정재호 ( Jae Ho Jeong )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2008년, 제5권 제4호, 903~909페이지(총7페이지)
파일형식
2a800292.pdf [무료 PDF 뷰어 다운로드]
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    According to the recent discovery of adipose tissue derived adult stem cells(ASCs), many researchers are working on ASCs for the possibility of clinical application. It has been already known that bone marrow stem cells, umbilical cord blood stem cells and vascular endothelial cells are effective in vascular regeneration within ischemic tissue. The purpose of this study is to confirm the angiogenic effect of differentiated endothelial progenitor cells(EPCs) from ASCs in ischemic hind limb model. In this study, as a control group, saline was injected for 12 rats and 1×107 EPCs were injected into muscular for ischemic hind limb. After 3 weeks, ischemic hind limb specimens were harvested and various techniques of analysis including fluorescence optical animal image system(Cell Visio, 488(R)), immunofluorescence, infrared thermography showed visual evidence of improved blood supply and new vessels in treated EPCs. Histological study was also revealed increased vascularization within ischemic tissue. It is obvious that EPCs from ASCs are an effective therapeutic agent for the revascularization of ischemic tissue.
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