Original Articles : Urinary nephrin: a new predictive marker for pregnancies with preeclampsia and small-forgestational age infants
분야
의약학 > 산부인과학
저자
( Kyung A Lee ) , ( Hye Sook Park ) , ( Young Ju Kim ) , ( Mi Hye Park ) , ( Sun Hee Chun ) , ( Eun Hee Ha ) , ( Ga Young Yang )
발행기관
대한산부인과학회
간행물정보
Obstetrics & Gynecology Science 2013년, 제56권 제1호, 22~28페이지(총7페이지)
파일형식
40326320.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Objective The objective of this study was to determine the differences in urinary nephrin among controls, gravidas with preeclampsia (PE), and small-for-gestational age (SGA) infants. We also determined whether or not maternal urinary concentrations of nephrin are associated with the subsequent development of PE and SGA infants. Methods We analyzed maternal urinary levels of nephrin in women who were normal controls (n=50), women who were delivered SGA infants (n=40), and gravidas with PE (n=33) in the first, second and third trimesters. Urinary nephrin concentrations were measured with nephrin enzyme-linked immunosorbent assay kits. Results The levels of urinary nephrin were higher in gravida developing preeclampsia or SGA than in controls after adjusting serum creatinine (P<0.05 for both). Maternal urine concentrations of nephrin were higher in pregnancies complicated by SGA and PE in the third trimester (P<0.05), and also higher in pregnancies complicated by SGA in the first trimester (P<0.05). The sensitivity and specificity of nephrin in predicting SGA from normal pregnancies were 67% and 89% in the first trimester, 60% and 79% in the second trimester, and 80% and 84% in the third trimester, respectively. The sensitivity and specificity of nephrin in predicting PE from normal pregnancies were 67% and 83% in the first trimester and 73% and 79% in the third trimester, respectively. Conclusion We suggest that urinary nephrin can be used as an early marker in pregnancies at risk for developing PE and SGA infants.
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