원저 : 레이저 시술 후 발생한 피부 장벽 손상과 자극 증상에 대한 APDDR-1001 제제 국소 도포의 효과
분야
의약학 > 피부과학
저자
김명신 ( Myoung Shin Kim ) , 허식 ( Sik Haw ) , 이형민 ( Hyung Min Lee ) , 김정환 ( Jeong Hwan Kim ) , 정연수 ( Yeon Su Jeong ) , 신홍주 ( Hong-ju Shin ) , 원종현 ( Chong Hyun Won ) , 장성은 ( Sung Eun Chang ) , 이미우 ( Mi Woo Lee ) , 최지호 ( Jee Ho Choi )
발행기관
대한피부과학회
간행물정보
대한피부과학회지 2012년, 제50권 제12호, 1017~1026페이지(총10페이지)
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27728556.pdf [무료 PDF 뷰어 다운로드]
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    Background: Because cosmetic laser treatments are getting popular, post-laser wound care becomes more important.Currently, topical moisturizers are reported to be sufficient to accelerate re-epithelialization and reduce downtime inpost-laser wound care.Objective: This study was performed to evaluate the effects of the moisturizer APDDR-1001 for post-laser woundcare, after ablative fractional laser on the face.Methods: In this double-blind, split-face study, 41 patients with photo-aged face received ablative fractional laser.They were divided into two groups, APDDR-1001 and vehicle (group 1) or control moisturizer (group 2), whichwere applied to the opposite sides of the face for 1 week after the laser treatment. The treatment efficacy wasevaluated by the transepidermal water loss (TEWL), erythema index, investigator`s assessment for recovery inerythema and overall improvement of the wound. Subjects ranked irritating symptoms and overall satisfaction ratingsin the overall improvement.Results: APDDR-1001 was well-tolerated and showed improvement in the erythema index and TEWL during the 7days of treatment. In group 2, improvement in erythema graded by investigators was significantly higher forAPDDR-1001 on day 3 (p<0.05). The overall improvement of wound ranked by investigators was significantlyhigher for APDDR-1001, compared with the controls in both groups. Subjective assessment demonstratedsignificantly less erythema (p=0.043), edema (p=0.041) and overall satisfaction ratings in the overall improvement (p<0.048) with APDDR-1001; however, no differences were detected in pain and edema between APDDR-1001 andvehicle (group 1). In group 2, subjects ranked ``much or very much improved`` in 75 % of APDDR-1001 side and55% of control moisturizer side. No significant differences in erythema, edema, pain and itching were reportedbetween APDDR-1001 and control moisturizer in group 2.Conclusion: The moisturizer APDDR-1001 demonstrated effective improvements in wound healing and subjectivesymptoms after ablative fractional laser therapy. (Korean J Dermatol 2012;50(12):1017∼1026)
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