Valaciclovir 복용 후 중추신경계 부작용을 보였던 복막투석 환자 1예
분야
의약학 > 기타(의약학)
저자
김준석 ( Joon Seok Kim ) , 양지은 ( Jee Eun Yang ) , 이보영 ( Bo Young Lee ) , 이서현 ( Seo Hyun Lee ) , 박희정 ( Hee Jung Park ) , 이선표 ( Sun Pyo Lee ) , 이상구 ( Sang Koo Lee )
발행기관
영남대학교 의과대학
간행물정보
영남의대학술지 2012년, 제29권 제2호, 121~124페이지(총4페이지)
파일형식
2u501171.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Valaciclovir is metabolized to acyclovir after ingestion and thereafter exerts its antiviral activity. Because of its superior pharmacokinetic profile, it has quickly replaced acyclovir in the treatment of herpesvirus infection. Neurotoxicity caused by valaciclovir has been reported, however, among patients with pre-existing impaired renal function. This paper reports a case of neurotoxicity of valaciclovir in a patient with end-stage renal disease who was undergoing continuous ambulatory peritoneal dialysis (CAPD). A 67-year-old female on CAPD took 500 mg of valaciclovir twice for herpes zoster. After she took her second dose orally, she developed confusion and disorientation, along with involuntary movements. Her mental confusion progressed to a coma. Discontinuation of valaciclovir showed no rapid improvement. There- fore, hemodialysis was started. After two sessions of hemodialysis, the patient became alert; and after four sessions of hemodialysis, her neurological abnormalities were completely reversed. In conclusion, valaciclovir can induce life-threatening neurotoxicity, especially in CAPD patients, even with appropriate dose reduction, which can be effectively managed by hemodialysis.
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