원보 : 손바닥선인장(Opuntia humifusa) 줄기 추출물의 항당뇨 효과
분야
의약학 > 약화학
저자
박철민 ( Chul Min Park ) , 곽병희 ( Byoung Hee Kwak ) , 서르마베스라즈 ( Bhesh Raj Sharma ) , 류동영 ( Dong Young Rhyu )
발행기관
한국생약학회
간행물정보
생약학회지 2012년, 제43권 제4호, 308~315페이지(총8페이지)
파일형식
05005007.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Opuntia humifusa known as the Eastern prickly pear have been used as a treatment of burns, diarrhea, asthma, rheumatism, gonorrhea, and diabetes in alternative medicine. O. humifusa is widely cultivated in the middle and southern provinces of Korea and distributed in North America. The aim of this study is to investigate anti-diabetic effect of O. humifusa stem (OHS) water or 80% MeOH extract using 3T3-L1 adipocytes and db/db mice animal models. OHS 80% MeOH extract at a dose of 250 μg/ml significantly increased the glucose uptake and lipid accumulation compared with the control in 3T3-L1 adipocytes. Blood glucose, plasma total cholesterol and triglyceride levels were significantly reduced by oral treatment of OHS 80% MeOH extract (200 mg/kg BW) for 6 weeks in db/db mice. Also, the oral treatment of OHS 80% MeOH extract slightly changed the plasma insulin and insulin resistance levels in db/db mice, but were no significance in comparison to control. Glucose transporter(GLUT)4 expressions of adipose tissue and muscle were significantly increased more than that in the control. Therefore, these results suggest that OHS 80% MeOH extract inhibits the blood glucose level through regulation of lipid profile, insulin resistance, and GLUT4 expression in db/db mice and its diabetic effect is effective more than water extract.
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