원보 : 삼출건비탕의 추출용매에 따른 성분 함량 및 효능 비교 연구
분야
의약학 > 약화학
저자
진성은 ( Seong Eun Jin ) , 서창섭 ( Chang Seob Seo ) , 하혜경 ( Hye Kyung Ha ) , 임혜선 ( Hye Sun Lim ) , 김예지 ( Ye Ji Kim ) , 전우영 ( Woo Young Jeon ) , 유새롬 ( Sae Rom Yoo ) , 김정훈 ( Jung Hoon Kim ) , 신인식 ( In Sik Shin ) , 김성실 ( Seong Sil Kim ) , 신나라 ( Na Ra Shin ) , 이미영
발행기관
한국생약학회
간행물정보
생약학회지 2012년, 제43권 제4호, 328~337페이지(총10페이지)
파일형식
05005010.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    In order to investigate anti-inflammatory, anti-allergic and anti-obesity activities of Samchulkunbi-tang (SCT; Shen zhu jian pi-tang) water and 70% ethanol (EtOH) extracts, in vitro inhibitory activities against nitric oxide (NO), prostaglandin E2 (PGE2), interleukin (IL)-6 and tumor necrosis factor (TNF)-α production in lipopolysaccharide-stimulated RAW 264.7 cells, and macrophage-derived chemokine (MDC/CCL22) and regulated on activation of normal T-cell-expressed and -secreted (RANTES/CCL5) production in TNF-α/interferon-γ-stimulated HaCaT and BEAS-2B cells as well as glycerol-3-phosphate dehydrogenase (GPDH) activity and leptin production in 3T3-L1 cells were determined. A HPLC was used for quantification of the seven marker components (albiflorin, paeoniflorin, liquiritin, naringin, hesperidin, poncirin and glycyrrhizin) of SCT water and 70% EtOH extracts. SCT showed inhibitory effects against MDC and RANTES production in HaCaT cells, as well as RANTES production in BEAS-2B cells. In addition, SCT reduced not only NO, PGE2, IL-6 and TNF-α production in RAW 264.7 cells, but also GPDH activity and leptin production in 3T3-L1 cells. Furthermore, the biological activities and the contents of six compounds (except paeoniflorin) were higher in 70% EtOH extract than water extract. These results suggest that SCT has anti-inflammatory, anti-allergic and anti-obesity activities. These efficacies of 70% EtOH extract are relatively higher than that of water extract.
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