Original Paper : Osteogenic Effects on Athymic Rat Calvarial Defects by Human Originated Cortical Bone
의약학 > 의공학
( Seog Jin Seo ) , ( Jae Won Heo ) , ( Ji Hwa Chae ) , ( Seong Hyun Jeon ) , ( Jin Kim ) , ( Nak Heon Kang ) , ( Kwang Won Lee ) , ( Ke Won Kang )
조직공학과 재생의학 2009년, 제6권 제1호, 9~14페이지(총6페이지)
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    The purpose of this study was to evaluate effects of bone regeneration by the external sources of human bone substitutes which were developed for the transplantation. There are many different forms of bone based substitute materials. This study is focused on transplantable bone products developed by HansBiomed Inc. and some selected products, namely, human cortical bone powder, demineralized bone matrix(DBM), and bovine bone powders. SureOss and SureFuse are freeze-dried form of human cortical bone powder and DBM combined products, available from HansBiomed Corp, Korea, and Bio-Oss is the granule form of bovine bone powder by Geistlich- Pharma, Switzerland. The 4-mm critical size skull defects in athymic rats were prepared, and the defects were filled with the materials to be tested. The animals were sacrificed at 12 weeks. New bone formation was assessed by optical, radiographic and histological analyses. In our results, photographical density showed that SureOss-graft model induced the best bone formation occurring from defect edges. In summary, our findings indicate that human cortical bone powder enhances bone formation in rat model and the new products based human cortical bone powder may be a good bone substitute material for allografts.
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