PVP의 분자량에 따른 시부트라민 고체분산체의 방출거동에 대한 영향
의약학 > 의공학
이준희 ( Jun Hee Lee ) , 양재찬 ( Jae Chan Yang ) , 이영현 ( Young Hyun Lee ) , 김대성 ( Dae Sung Kim ) , 김원 ( Won Kim ) , 박종학 ( Jong Hak Park ) , 안식일 ( Sik Il Ahn ) , 김윤태 ( Yun Tae Kim ) , 이동원 ( Dong Won Lee ) , 이종문 ( John M Rhee ) , 강길선 ( Gil Son Khang )
조직공학과 재생의학 2009년, 제6권 제1호, 148~154페이지(총7페이지)
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    The aim of this study was designed to evaluate properties and dissolution rates of sibutramine solid dispersions by spray drying. Sibutramine as appetite depressant for obesity treatment is soluble in low pH but insoluble in high pH. To improve bioavailability, it should be improve dissolution rate in pH 6.8 because sibutramine is absorbed at the small intestinal track. PVP has various molecular weights according to K values. We investigated effect of molecular weights of PVP on the release behavior of solid dispersion. DSC and XRD were used to analyze the crystallinity of the sample. It was found that sibutramine is amorphous in the solid dispersions. FT-IR was used to analyze the salt formation by hydrogen bond between sibutramine and PVP. As a result of in vitro release behavior, solid dispersion using PVP K30 is obtained good possibility of orally pharmaceutical formulation. This study proposed that this solid dispersion system controlled the release behavior according to molecular weights.
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