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분야
의약학 > 의공학
저자
이은정 ( Eun Jung Lee ) , 전성현 ( Seong Hyun Jeon ) , 채지화 ( Ji Hwa Chae ) , 허재원 ( Jae Won Heo ) , 강계원 ( Ke Won Kang ) , 김진 ( Jin Kim ) , 김경표 ( Kyoung Pyo Kim ) , 이광원 ( Kwang Won Lee )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제1호, 287~293페이지(총7페이지)
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2a800338.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Calcium sulfate is widely used for bone grafts as binder and expander. It was also reported that carboxymethylcellulose(CMC) can improve chemical characteristics for clinical applications when it is used as binder of calcium sulfate and demineralized bone matrix(DBM) for particulate bone grafts. DBM is an osteoinductive material which has been used to reconstruct bone tissue in maxillocraniofacial surgery, periodontics, and orthopedics. In this study, the effects of CMC-based putties containing DBM and/or calcium sulfate hemihydrate were evaluated in rat skull defects. Radiographs and histological evaluation of defect area after a period of time showed healing progress and new bone appeared greater for the treatment of CMC-based calcium sulfate hemihydrate putty compared to the untreated defect. When DBM was added to the putty, the most prominent bone regeneration effect was observed. We conclude that fast-resorbing CMC-based calcium sulfate hemihydrate putty containing DBM is effective for healing from the defective bone. CMC-based calcium sulfate may be used as a carrier and binder of bone graft materials for the restoration of bony defects.
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