Original Paper : In Vitro and In Vivo Biocompatibility of r-ray Crosslinked Gelatin-Poly(vinyl Alcohol) Hydrogels
분야
의약학 > 의공학
저자
( Kyoung Hee Seo ) , ( Su Jung You ) , ( Heung Jae Chun ) , ( Chun Ho Kim ) , ( Who Kyong Lee ) , ( Yoon Mook Lim ) , ( Young Chang Nho ) , ( Ju Woong Jang )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 414~418페이지(총5페이지)
파일형식
2a800354.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Previously cross-linked hydrogels for three dimensional scaffold were made from a mixture of poly(vinyl alcohol)(PVA) and gelatin using a 60Co r-ray irradiation technique. These hydrogels exhibited desirable physical properties as the 3D constructs for diploid cell cultures. The cell adhesion in the hydrogels increased upon increasing the gelatin content. In addition, the cells cultured in gelatin containing hydrogels showed the improved spreading ability and growth ratio. As a continuation study, biocompatibility profiles of gelatin-poly(vinyl alcohol) hydrogels were investigated in vitro and in vivo, in accordance with the ISO 10993-5. Test results were cpmapred to polyurethane(PU) as a positive control and low-density poly ethylene(LDPE) as a negative control.Although the results have small differences with respect to the gelatin contents, all samples showed negligible toxicity to the cells and tissues.
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