골수유래 간엽줄기세포의 조건배지가 Ntera-2 인간신경세포의 신경돌기 성장에 미치는 영향
분야
의약학 > 의공학
저자
오진수 ( Jin Soo Oh ) , ( Meng Lu Liu ) , ( Hong Lian Jin ) , 안성수 ( Sung Su An ) , 김긍년 ( Keung Nyun Kim ) , 윤도흠 ( Do Heum Yoon ) , 하윤 ( Yoon Ha )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 562~567페이지(총6페이지)
파일형식
2a800373.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Bone marrow derived mesenchymal stem cell(BMSC) based cell therapy can promote functional recovery and regeneration in central nervous system(CNS) disease models. These beneficial effects have been primarily attributed to the differentiation potential into varieties of cell lineages and the therapeutic paracrine factors secreted by BMSC after transplantation. Many secreted factors from BMSC have been identified recently in the conditioned media. However, the effects of these factors on the neuronal regeneration need further verification with relevant neuronal models. Ntera-2 neurons have been used for the therapy of several different CNS diseases in animal models. Recently some clinical trials have confirmed the safety and potential efficacy of Ntera-2 neurons for stroke therapy. In this study, the Ntera-2 neuron model was used to directly verify the effect of BMSC conditioned media(BMSCCM) on neurite outgrowth in vitro. Our study confirmed that the BMSC-CM could increase both the neurite length and branch number of Ntera-2 neurons, compared to the control group with non-conditioning media. Since the BMSC can secret many therapeutic factors into the conditioned media, our data support the theory that BMSC promote neurite outgrowth through secreting paracrine factors.
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