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분야
의약학 > 의공학
저자
최용수 ( Yong Soo Choi ) , 노상은 ( Sang Eun Noh ) , 이창우 ( Chang Woo Lee ) , 임상민 ( Sang Min Lim ) , 최성훈 ( Sung Hun Choi ) , 김동일 ( Dong Il Kim )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 615~622페이지(총8페이지)
파일형식
2a800381.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Tissue-engineered osteochondral composites were developed using multipotent periosteum-derived progenitor cells(PDPCs) with different scaffolds. After respective differentiation of PDPCs into cartilage and bone tissues in atelocollagen gel and calcium phosphate scaffolds for four weeks, the two tissues were sutured together and cultured for one more week. Immunophenotypes, quantitative RT-PCR, and histological analysis were performed for the evaluation of multipotency of PDPCs. PDPCs were successfully differentiated into chondrocytes and osteocytes in different scaffolds. Also, we confirmed that theses tissue-engineered osteochondral composites were adherent well with each other. Moreover, tissue-engineered tissues were similar with natural ones. Therefore, PDPCs were useful alternative cell sources for the generation of tissue-engineered osteochondral tissues and they could be used for the treatment of full-thickness defected cartilage in the future.
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