피브로넥틴과 펠렛배양이 골막유래 전구세포의 인슐린 생산 세포로의 분화에 미치는 영향
분야
의약학 > 의공학
저자
박부영 ( Bu Young Park ) , 김종일 ( Jong Il Kim ) , 전형진 ( Hyung Jin Jeon ) , 최성훈 ( Sung Hun Choi ) , 이창우 ( Chang Woo Lee ) , 임상민 ( Sang Min Lim ) , 김동일 ( Dong Il Kim )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 636~646페이지(총11페이지)
파일형식
2a800384.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Type 1 diabetes is caused by a progressive destruction of insulin-producing cells(IPCs) by an autoimmune disease. Islet transplantation is considered as the most effective treatment for type 1 diabetes, but it is hindered by limited supply of islets. Mesenchymal stem cells(MSCs) can be isolated from several tissues and used in the differentiation into mesodermal cell types. Periosteum-derived progenitor cells(PDPCs), which have similar characteristics with MSCs, were easily isolated with high growth potency. Using a three-step differentiation protocol, PDPCs could be differentiated into IPCs. IPCs derived from PDPCs were evaluated by using microscope, RT-PCR and immunostaining. When three-dimensional suspension cultures were performed with the addition of fibronectin and various extracellular matrix(ECM), it was clear that PDPCs could differentiate into IPCs. Under optimized culture conditions, improved differentiation of PDPCs into IPCs was possible.
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