Original Paper : A Comparative Study of the Osteogenic Potentials of rhBMP-2 in Collagen Sponge or Mixed with Porcine Collagen Gel in a Rat Spinal Fusion Model
의약학 > 의공학
( Kyoung Ho Moon ) , ( In Suh Park ) , ( Mi Ok Lee ) , ( Hyung Chun Park ) , ( Chong Oon Park ) , ( Dong Keun Hyun ) , ( Hyeon Seon Park ) , ( Eun Young Kim ) , ( Kil Whan Kim ) , ( Byung Hyune Choi ) , ( So Ra Park ) , ( Dae Cheol Rim ) , ( Seung Hwan Yo
조직공학과 재생의학 2009년, 제6권 제4호, 653~658페이지(총6페이지)
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    To identify an ideal carrier for rhBMP-2 during spinal fusion surgery, we produced a posterolateral rats lumbar fusion model to compare the bone induction potentials of rhBMP in collagen sponge(CS) and rhBMP-2 mixed with insoluble porcine collagen(PC) gel. Forty Sprague-Dawley rats(350-400 grams) subjected to bilateral lumbar intertransverse process fusion were allocated to CS Groups(Groups 1 to 4) or PC gel Groups(Group 5 to 8). Group 1 animals were implanted with CS and injected with 1 ?g rhBMP-2; Group 2 with CS plus 3 ?g rhBMP-2; Group 3 with CS plus 5 ?g rhBMP-2; Group 4 with CS plus 10 ?g rhBMP-2; Group 5 with PC gel containing 1 ?g rhBMP-2; Group 6 with PC gel plus 3 ?g rhBMP-2; Group 7 with PC gel plus 5 ?g rhBMP-2; and Group 8 with PC gel plus 10 ?g rhBMP-2. Spinal fusion masses were evaluated by manual palpation, radiographic assessment, microcomputer tomographic scanning, and histologically at 8 weeks after surgery. Bone fusion was radiologically confirmed in 50% in Group 3, 66% in Group 4, 16.7% in Group 5, 20% in Group 6, 80% in Group 7, and 100% in Group 8. Treatment with PC gel plus rhBMP-2 resulted in higher spinal fusion rates than CS plus rhBMP-2 based on manual palpation, microCT, and histologic examinations(P < 0.01). In this study, the mixing of gelatin gel and rhBMP-2 resulted in more effective lumbar intertransverse process fusion than injecting collagen containing rhBMP-2.
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