골다공증 유도 백서에서 칼슘과 비타민 D 섭취 후 임플랜트 주위 뼈 조직에서 TGF-β1, 데코린 및 바이글리칸 발현에 관한 연구
분야
의약학 > 의공학
저자
신상훈 ( Sang Hun Shin ) , 이기혁 ( Ki Hyug Lee ) , 이재열 ( Jae Yeol Lee ) , 강영훈 ( Young Hoon Kang ) , 김용덕 ( Yong Deok Kim ) , 김규천 ( Gyoo Cheon Kim )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 693~699페이지(총7페이지)
파일형식
2a800392.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Because osteoporosis is known to influence the late period of bone healing, bone formation around titanium implant is deteriorated in osteoporotic patient. The purpose of this study was to investigate the effect of calcium and vitamin D diet on the expressions of TGF-β1, decorin and biglycan in the peri-implant bone of induced osteoporotic rats. After 40 rats, 10 weeks of age, were ovarietomized, 20 rats were supplemented with calcium and vitamin D as a experimental group and 20 rats were without calcium and vitamin D as a control group. Titanium screw implant(Cowellmedi, KOREA, diameter, 2.0 mm; length, 3.5 mm; pitch-height 0.4 mm) were planted into tibia of 40 rats. The rats were sacrificed at different time interval(1, 2, and 4 weeks after implantation) and then immunohistochemistry for the expression of TGF-β1, decorin and biglycan was performed. The expression level of TGF-β1 and decorin in experimental groups was much higher than the control group at 1 week. The expression of biglycan in control group was observed at 1 and 2 weeks and this expression level was higher than that of experimental group. Considering calcium and vitamin D diet increased the expression of TGF-β1 and decorin in osteoporotic rats, we suggest that those diet might help early bone formation around titanium implant in osteoporotic patients.
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