미니피그에서 임플란트 주위의 골결손부에 대한 I형 콜라겐, 조골세포 및 PTH의 골형성 효과
분야
의약학 > 의공학
저자
이준 ( Jun Lee ) , 장재덕 ( Jae Deog Jang )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 700~710페이지(총11페이지)
파일형식
2a800393.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    5,100원
    적립금
    153원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    영문초록
    Effect of type I collagen, osteoblast and PTH mixture on bone formation of the bony defects around implant in minipigs. Mesenchymal stem cells derived from adult bone marrow are multipotent cells capable of differentiating along several lineage pathways. Cell-driven approaches, especially the biophysical stimulation of the host cell population surrounded by the bone defect, are common treatment methods in maxillofacial surgery. Others, such as autogenous cell implantation, have now gained acceptance for clinical trials. All of the cell-driven repair strategies are under intensive investigation in an effort to provide surgeons with a limitless supply of tissue for bone repair and reconstruction in future procedures. An overview of the basic biological aspects as well as the inherent constraints of different cell-based approaches are given in this paper. The aim of this study was to evaluate the bone formation effects of mesenchymal stem cells & PTH as a cytokine in bone defects around implants in Minipig models. Ten minipigs were divided into 4 groups. We made 4 wall-defects(10 mm in diameter, 8 mm in height) on the lower jaw, and the following materials were applied: fibrin glue as control and type I collagen, type I collagen + osteoblast, and type I collagen + osteoblast + PTH as experimental groups. Each defects were implanted with 3 mm wide and 8 mm long implants in center. Experimental minipigs were sacrificed at 1, 2, 4, 8 and 12 weeks after operation. We evaluated the defects clinically, histologically and histomorphologically(bone implant contact). The results were as follows; (1) Osteogenesis in Type I collagen mixed with osteoblast and osteoblast with PTH groups was more active than control group. (2) Most experimental groups, especially the PTH group, at 4 weeks to 8 weeks, showed larger amount of bone implant contact increase than control group.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.