하이아루론산을 기재로 한 하이드로젤-나노입자 복합체와 rhBMP-2를 이용한 골재생
분야
의약학 > 의공학
저자
이종호 ( Jong Ho Lee ) , 김성민 ( Soung Min Kim ) , 박종철 ( Jong Chul Park ) , 성미애 ( Mi Ae Sung ) , 유상배 ( Sang Bae Yu ) , 남정훈 ( Jeong Hun Nam ) , 정용일 ( Yong Il Chung ) , 김정주 ( Jung Ju Kim ) , 박용두 ( Yong Doo Park ) , 태기융 ( Gi Yoong Tae )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 730~738페이지(총9페이지)
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2a800397.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    As an efficient controlled release system of rhBMP-2, a functional nanoparticle-130 KDa 5% Hyaluronic Acid (HA) based hydrogel-Nanoparticle(NP) complex was developed and used as a bone transplant. In vivo bone formation was evaluated by soft x-ray, histology, alkaline phosphatase (ALP)/Osteocalcin activity and mineral contents analysis, based on the rat calvarial critical size defect (8 mm in diameter) model. Significantly, effective bone regeneration was achieved with the rhBMP-2 loaded HA based hydrogel-NP complex and the BMP-2 loaded HA based hydrogel as compared to only HA hydrogel group with the period of 4 weeks. These improved results included areas such as radiodensity, the bone specific ALP activity, the osteocalcin immunoreactivity, and the ratio of calcium and phosphate contents with respect to normal bone in the regenerated bone area. Although superiority of bone regenration in the rhBMP-2 loaded HA based hydrogel-NP complex group could not be confirmed statistically, all the evaluation parameters were higher in the rhBMP-2 loaded HA based hydrogel-NP complex group than in the the BMP-2 loaded HA based hydrogel group. These results indicate that the HA based hydrogel with nanoparticle complex can be a promising candidate for a new bone defect replacement matrix, and an enhanced BMP-2 scaffold.
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