SIS/PLGA 필름에서 SIS 함량이 신경계 세포의 부착과 증식에 미치는 영향
의약학 > 의공학
김초민 ( Cho Min Kim ) , 김순희 ( Soon Hee Kim ) , 송이슬 ( Yi Seul Song ) , 정수현 ( Su Hyun Jung ) , 김혜린 ( Hye Lin Kim ) , 오재민 ( Jae Min Oh ) , 박종학 ( Jong Hak Park ) , 이동원 ( Dong Won Lee ) , 이종문 ( John M Rhee ) , 강길선 ( Gil Son Khang )
조직공학과 재생의학 2009년, 제6권 제4호, 825~832페이지(총8페이지)
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    Porcine small intestinal submucosa(SIS) derived from the submucosal layer of porcine intestine, both generate a minimal inflammatory response following implantation and have been approved by the FDA for many types of biomedical applications. Poly(lactic-co-glycolic acid)(PLGA) is a biodegradable synthetic polymer with acceptable mechanical strength and well-controlled degradation rate. Also, it can be easily fabricated into many shapes. In this study, we fabricated natural/synthetic biomaterial hybrid films using 0, 10, 20, 40 and 80 wt% of SIS. Schwann cells(SCs) and olfactory ensheathing cells(OECs) were seeded on SIS/PLGA film and confirmed the effects of adhesion and proliferation on SCs and OECs according to content of SIS. We confirmed that specific 10~20 wt% SIS in SIS/PLGA films was superior to adhesion and proliferation of SCs and OECs and content of SIS such as 40 wt% and 80 wt% could not help cell growth and proliferation.
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