Original Paper : Angiogenic Squamous Dysplasia as a Biomarker to Predict Progression to Lung Cancer
분야
의약학 > 의공학
저자
( Chul Ho Oak ) , ( Tae Won Jang ) , ( Maan Hong Jung ) , ( Bong Kwon Chun ) , ( Soon Kew Park )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 855~861페이지(총7페이지)
파일형식
2a800411.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    4,500원
    적립금
    135원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    영문초록
    Angiogenic squamous dysplasia(ASD) is a term that has been introduced to describe a neoangiogenesis seen in bronchial dysplasias. One of many important angiogenic cytokines are the VEGFs. The VEGFs and their receptors are prime regulators of both physiological and pathological angiogenesis. But it is not clear whether ASD demonstrates the angiogenic switch or not, what is the mechanism of ASD. In this study, Immunohistochemical studies showed an expression of vascular endothelial growth factor in dysplastic bronchial epithelium. VEGF in the dysplastic cells in preneoplastic epithelium was observed in twenty-nine of 31 patients with ASD(93.5%), indicating that angiogenic switch occurred in early preneoplastic lesion including hyperplasia, metaplasia. ASD lesions were not identified in patients with COPD, whereas in 31 of 90 (34.4%) patients with squamous carcinoma, ASD was evident. In addition, the incidence of ASD increased as the hisological grade of preneoplastic lesion advanced, suggesting that the ASD may be a direct precursor lesion(P = 0.03). The author followed up the biologic behavior of dysplasia with respect to the status of ASD. There were significant associations between histological outcome and ASD status during the follow-up period(P = 0.04). These results suggested that ASD be used as biomarkers to predict which dysplasias will progress to squamous cell carcinoma. Macrophages were identified in all(100%) tumor stroma and ASDs. The number of macrophage beneath ASD was significantly higher than that beneath other abnormal epithelium. In addition, the number of macrophages beneath ASD was significantly correlated with the count of microvessels beneath ASD. The results of the present study suggested that Angiogenic squamous dyplasia(ASD) may represent an precursor of lung cancer and may serve as an useful intermediate pathologic biomarker for early detection of lung cancer and chemoprevention. Macrophage beneath ASD may play an important role in early angiogenesis of ASD.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.