임플란트-조직 계면에서의 부착단백질의 역할
분야
의약학 > 의공학
저자
박지선 ( Ji Sun Park ) , 이재봉 ( Jae Bong Lee ) , 김진 ( Jin Kim ) , 임영준 ( Young Jun Lim )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 875~881페이지(총7페이지)
파일형식
2a800414.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Upon fixture implantation, the first interaction between the fixture and the host organism begins at the surface of the fixture as it encounters the blood and the interstitial fluid of the host. Especially, molecules including proteins, derived from the body fluid, adsorbs to the surface of the fixture, and the process of it acts as a signal forwarding following biological reactions, rendering various cells to go through adhesion and reorganization, which enables osseointegration of the fixture within the bone structure. In this review, adhesion proteins that are known to adsorb to the implant surface in initial stage are focused. First, the general process, mediated through adhesion proteins such as integrins in the micro-environment consisting of the surface and cells, are reviewed. Next, the studies of adhesion proteins in vitro and in vivo are discussed. Lastly, this paper will describe how these proteins can affect cell spreading, proliferation and differentiation in the implant- tissue interface. An understanding of the special features of the adhesion proteins and their receptors is a prerequisite for the development of novel implant surfaces.
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