Original Paper : Guided Bone Regeneration Effect by Chitosan/Hydroxyapatite Membrane on Repair of Rat Calvarial Defect
의약학 > 의공학
( Shi Hyun Lee ) , ( Bok Joo Kim ) , ( Sang Hun Shin ) , ( Hong Sung Kim ) , ( Kyu Cheon Kim ) , ( Cheol Hun Kim ) , ( Young Hoon Kang ) , ( Ji Bong Jo )
조직공학과 재생의학 2009년, 제6권 제4호, 916~923페이지(총8페이지)
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    The synthetic scaffolds for bone augmentation fill the cavity, and act as a template for initial cell ingrowth and subsequent tissue formation. The desirable material as a scaffold need resorbable biomimetics, biocompatibility, mechanical stability, and cell viability. Hydroxyapatite is a synthetic calcium phosphate that resembles bone mineral. Its surface is highly reactive and favorable for attachment. Hydroxyapatite has properties such as biocompatibility, non-toxicity, osseoconductivity. And chitosan is one of the biodegradable polymers in nature. Chitosan has non-toxicity, flexibility, anti-bacterial effect, resistance to heat, and biocompatibility. Mixture of hydroxyapatite and chitosan promotes osteoblastic adhesion, migration, differentiation, and proliferation. This mixture were prepared for the function of guided bone regeneration(GBR). This study makes the chitosan/fibroin-hydroxyapatite composite membrane be a prospective biodegradable GBR membrane for future applications.
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