Original Paper : The Comparison between Human Hertwig`s Epithelial Root Sheath Cells and Periodontal Ligament Stem Cells
분야
의약학 > 의공학
저자
( Hyun Nam ) , ( Hyun Jeong Kweon ) , ( Soo Yeon You ) , ( Dae Hyun Jeon ) , ( Jae Jin Cho ) , ( Gene Lee )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 931~937페이지(총7페이지)
파일형식
2a800423.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    4,500원
    적립금
    135원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    영문초록
    It is well known that the interactions between epithelial and mesenchymal components are very important event for tooth development, and their coordination is crucial to tooth development. Recently it has been reported that human PDLSC might be a mesenchymal component for regeneration of periodontal tissue. In contrast, characteristics of human HERS cells and their roles in development and regeneration of tooth are not well elucidated. In this study, we investigated the phenotypes and the differentiation potentials of human HERS cells and PDLSCs. First of all, we simultaneously isolated human HERS cells and PDLSCs from the same periodontal ligament tissues. Hence we established the method for primary isolation of human HERS cells and PDLSC at the same time. Human HERS cells and PDLSCs showed different cell morphology and growth patterns from each other. In particular, human HERS cells showed epithelial cell-like morphology, while human PDLSCs showed fibroblast-like morphology. In the immunophenotype analysis of cell surface markers, human PDLSCs were positive for the mesenchymal stem cell markers but human HERS cells showed different expressions. Human PDLSCs were able to differentiate into osteoblasts and adipocytes by appropriate induction. On the other hand, human HERS cells acquired mesenchymal phenotypes by TGF-β1 through EMT. Taken together, our data suggest that human HERS cells and PDLSCs might play a role as a epithelial component or a mesenchymal component for the tooth regeneration,v respectively.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.