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분야
의약학 > 의공학
저자
박종학 ( Jong Hak Park ) , 김세호 ( Se Ho Kim ) , 오재민 ( Jae Min Oh ) , 안식일 ( Sik Il Ahn ) , 김윤태 ( Yun Tae Kim ) , 정수현 ( Su Hyun Jung ) , 최진희 ( Jin Hee Choi ) , 이동원 ( Dong Won Lee ) , 유일수 ( Il Sou Yoo ) , 이종문 ( John M Rhee ) , 강길선 ( Gil Son Khang )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 995~1002페이지(총8페이지)
파일형식
2a800431.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    The aim of this study was to improve dissolution rate and controlled release of poorly water-soluble drug, cilostazol, using general water soluble polymers. We prepared solid dispersed cilostazol with hydrophilic polymer, Poly-N-Vinylpyrolidone(PVP), Plasdone S630, Hydroxypropylmethylcellulose(HPMC), PEG 6000, Eudragit E100, and surfactant, Poloxamer 407. Characterization of cilostazol solid dispersion analyzed by scanning electron microscope(SEM), differential scanning calorimeter(DSC) and infrared spectrometry(FT-IR). SEM and DSC were found that amorphous in solid dispersion. Particle size analyzer was used to investigate size of cilostazol in solid dispersion. The in vitro release behavior of solid dispersion presented at simulated gastric fluid(pH 1.2). The release behavior of cilostazol was controlled release with hydrophilic polymers and solid dispersed cilostazol with hydrophilic polymers was sustained release behavior than initial burst release of commercial drug(Pletal(R)). This studies suggest that this solid dispersion system with hydrophilic polymers controlled poorly water-soluble drug, cilostazol, release behaviors.
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