방사선조사 창상에 대한 지방유래 줄기세포의 효과
분야
의약학 > 의공학
저자
허찬영 ( Chan Yeong Heo ) , 이은혜 ( Eun Hye Lee ) , 강혜인 ( Hye In Kang ) , 김인아 ( In Ah Kim ) , 은석찬 ( Seok Chan Eun ) , 백롱민 ( Rong Min Baek ) , 민경원 ( Kyung Won Minn )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 1019~1022페이지(총4페이지)
파일형식
2a800434.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Radiation-induced skin wound is a unwanted complication of radiation therapy in cancer patients. Because a putative potential stem cell population within the adipose tissue has been found to possess therapeutic potentials, we authors sought to determine the effect of adipose tissue-derived stem cells(ADSCs) on radiationinduce skin wound. Sprague-Dawley rats were divided into two groups. Adipose tissue-derived stem cells were isolated from the inguinal fat pads and expanded ex vivo for three passages. All groups received 25 Gy of gamma irradiation as a single dose to the back of the rats using a cobalt-60 teletherapy unit. After four weeks of radiation, syngeneic ADSCs were delivered into the subcutaneous area of irradiated wounded skin area in experimental group. Acute skin reactions were assessed and at the endpoint of the study. Light microscopic findings were assessed. Clinically and histopathologically, radiation skin reactions were lower than control group(p<0.05). ADSCs was found to be efficacious in preventing epidermal atrophy, dermal degeneration and hair follicle atrophy. In conclusion, ADSCs could be used as useful cell therapeutics to repair and regenerate the wound of irradiation damage.
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