약물투과향상을 위한 손톱의 특성변화에 관한 연구
분야
의약학 > 의공학
저자
안식일 ( Sik Il Ahn ) , 엄신 ( Shin Eom ) , 김용기 ( Yong Ki Kim ) , 김대성 ( Dae Sung Kim ) , 김원 ( Won Kim ) , 전나리 ( Na Ri Jeon ) , 이동원 ( Dong Won Lee ) , 이종문 ( John M Rhee ) , 강길선 ( Gil Son Khang )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 1035~1040페이지(총6페이지)
파일형식
2a800437.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    There are two methods to treating onychomycosis. They are oral therapy and topical therapy. In this study we investigated the topical therapy. Penetration enhancer is necessary for effective topical dose of nail. KOH, NaOH and NaBH4 that have a potentiality as a penetration enhancer were dissolved in distilled water at 3% w/v concentration. And then nails are treated with penetration enhancers. The nail swelling rate(%) is calculated by using the nail weight of before and after experiment. The nails treated with penetration enhancer are fully dried and then we observed the surface of nails by using SEM and AFM. The three potential penetration enhancers showed high nail swelling rate and the surface of nails was more lifted than non-treating group or control group. So three penetration enhancers as enhancing the drug penetration are excellent.
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