염산 트라마돌을 함유하는 PLGA 미립구의 제조 및 방출거동
분야
의약학 > 의공학
저자
박종학 ( Jong Hak Park ) , 엄신 ( Shin Eom ) , 안식일 ( Sik Il Ahn ) , 김대성 ( Dae Sung Kim ) , 김원 ( Won Kim ) , 이동원 ( Dong Won Lee ) , 유일수 ( Il Sou Yoo ) , 이종문 ( John M Rhee ) , 강길선 ( Gil Son Khang )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2009년, 제6권 제4호, 1041~1047페이지(총7페이지)
파일형식
2a800438.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Tramadol HCl(TH)-loaded poly(L-lactide-co-glycolide)(PLGA) microspheres were prepared by O/O solvent evaporation method for sustained release. We investigated the release behavior according to PLGA molecular weight and concentration. TH-loaded PLGA microspheres were characterized on the surface and cross-section morphology by SEM. TH-loaded PLGA microspheres had smooth surfaces and various pores in internal structure. As the PLGA molecular weight and PLGA concentration increased, the release rate of TH decreased. The behaviors of degradation was decreased according to increased PLGA molecular weight. These results showed that the release behaviors can be controlled by various of molecular weight and concentration of PLGA.
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