Influence of Surface Area Parameters and Water Contact Angles on the Early Differentiation of MG63 Human Osteoblast-Like Cells Cultured on Micro-Grooved Titanium Substrata: a Pilot Study

분야: 의약학 > 의공학
저자: ( Sung Eun Kim ) , ( Young Pil Yun ) , ( Suk Won Lee ) , ( Il Keun Kwon ) , ( Su Jin Ahn ) , ( Richard Leesungbok )
발행기관: 한국조직공학·재생의학회
간행물정보: 조직공학과 재생의학 2010년, 제7권 제2호, 68~76페이지(총9페이지)
파일형식: 2a800531.pdf [무료 PDF 뷰어 다운로드]
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연관 논문

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영문초록

The purpose of this study was to determine the influential factors on the early osteoblastic differentiation of MG63 osteoblast-like cells cultured on micro-grooved Ti substrata. Commercially pure Ti discs with surface microgrooves of various dimensions were fabricated using photolithography. Both ground and acid-etched Ti were used as controls. Surface widths of the Ti substrata were calculated and used as the surface area parameters. These surfaces were characterized by X-ray photoelectron spectroscopy (XPS) and water contact angle (WCA). Early osteoblastic differentiation of MG63 human osteoblast-like cells were analyzed using an alkaline phosphatase (ALP) activity test. Pearson`s correlation analysis and multiple regression analysis were used to analyze the correlations between experimental results and to determine the influential factors on osteoblastic differentiation, respectively. The results of experiments showed significant correlations between surface properties and osteoblastic differentiation. Surface width was determined to be the greatest influential factor on the ALP activity after 1 day of osteogenic culture. The water contact angles measured in perpendicular directions to the microgrooves showed greatest influence on the ALP activity on day 7. This study indicates that the factors influencing the early osteoblastic differentiation on micro-grooved Ti substrata show respective time-dependence.

#titanium substrata # microgrooves # surface area # water contact angle # osteoblastic differentiation

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