동종 탈회 골 기질의 골 재생 촉진 효과
분야
의약학 > 의공학
저자
강수환 ( Soo Hwan Kang ) , 정양국 ( Yang Guk Chung ) , 이윤경 ( Yun Gyoung Lee ) , 김양수 ( Yang Soo Kim ) , 김용식 ( Yong Sik Kim ) , 김정만 ( Jung Man Kim ) , 박세욱 ( Se Wook Park )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2010년, 제7권 제4호, 373~380페이지(총8페이지)
파일형식
2a800555.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    The purpose of this study is to investigate the efficacy of bone regeneration of combined demineralized bone matrix (DBM) and osteoconductive allogeneic cancellous bone granule implantation in critical size bone defect, rabbit radius model. We grafted the mixture of DBM and allogeneic cancellous bone granules in the experimental group, and the mixture of autoclaved DBM and allogeneic cancellous bone granules in the control group in 30 New Zealand White rabbits. At the 3, 6, 9, and 12 weeks post-implantation, radiographic and bone mineral density BMD evaluation were performed, and micro-CT and histologic assessments were performed with 6 and 12 week specimens. In comparison of the results of radiographic, BMD, and micro-CT evaluations, the experimental group showed much more and earlier bone formation than the control group, which indicated the enhanced bone regeneration by the effect of DBM on allogeneic cancellous bone granule scaffolds. Histologic evaluation also revealed rapid bone resorption, new bone formation, and maturation in experimental groups. There was no inflammatory or foreign body giant cell infiltration suggesting biologic incompatibility. Combined DBM and allogeneic cancellous bone granule composite grafts will be useful alternatives to autogenous bone grafts in various clinical conditions which require bone regeneration.
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