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분야
의약학 > 의공학
저자
김치훈 ( Chi Hoon Kim ) , 우대곤 ( Dae Gon Woo ) , 박지형 ( Ji Hyung Park ) , 전옥희 ( Ok Hee Jeon ) , 이승학 ( Seung Hak Lee ) , 김지현 ( Chi Hyun Kim ) , 윤대성 ( Dae Sung Yoon ) , 김한성 ( Han Sung Kim )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2010년, 제7권 제4호, 381~387페이지(총7페이지)
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2a800556.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    The present study was designed to evaluate the correlation between osteoporosis and osteoarthritis, based on micro-computed tomography (Micro-CT) and atomic force microscopy (AFM). To induce osteoporosis, virgin Sprague-Dawley rats (6 weeks old) were ovariectomized (OVX). All rats were randomly divided in two groups (normal group: 9, OVX group: 6). Knee joint on each rat was scanned by Micro-CT with 18-μm resolution at 0, 4 and 8 weeks. Morphological characteristics were calculated by Micro-CT image analyzer. Knee joint chondrocytes were isolated and immobilized to investigate morphological and mechanical characteristics on AFM measurements. In the OVX group, morphological characteristics significantly changed at all the femur over time(p<0.05). Comparing OVX group to normal group at 8 weeks, morphological characteristics and stiffness of chondrocytes measured by AFM significantly increased in normal group more than OVX group(p<0.05). The results showed that osteoporosis can cause osteoarthritis. The finding of the present study indicated that AFM can analyze the origin of osteoarthritis. In addition, this study is valuable attempt to find the correlation between osteoporosis and osteoarthritis.
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