Original Article : In Vivo Study of a Blended Hydrogel Composed of Pluronic F-127-Alginate-Hyaluronic Acid for its Cell Injection Application
의약학 > 의공학
( Syed Izhar Haider Abdi ) , ( Jeong Yeon Choi ) , ( Ji Seon Lee ) , ( Hyun Ju Lim ) , ( Chang Ho Lee ) , ( Jee Hyun Kim ) , ( Ho Yun Chung ) , ( Jeong Ok Lim )
조직공학과 재생의학 2012년, 제9권 제1호, 1~9페이지(총9페이지)
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    The epitome that cell carrier serves solely as passive vehicles has become outdated. It is now evident that the carrier microenvironment also contributes in the regeneration process. In this study, a combination of alginate, pluronic F127 and extracellular matrix (ECM) component, hyaluronic acid (HA) based scaffold has been prepared for in situ gelling vehicles for muscle cells. ECM incorporated blended hydrogel showed enhanced uniform distribution of muscle cells in a nude mouse model forming the scaffold in situ allowed the muscle cells to proliferate efficiently, indicating that a pluronic F127/alginate/HA matrix provided a beneficial environment for cellular growth and expansion. The formation of gel beneath the skin of nude mice was confirmed using optical coherence tomography (OCT). OCT has been used to visualize the in situ localization of cells as well. This in situ gelation is found to be advantageous for regenerative applications due to the absence of toxic solvents or co-polymerization agents; besides the handling process is simple. This study demonstrates that an in situ blended hydrogels enables the favorable settlement of cells and satisfactory cell delivery for muscle regeneration applications.
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