Original Article : Hydrogel Incorporated with Chestnut Honey Accelerates Wound Healing and Promotes Early HO-1 Protein Expression in Diabetic (db/db) Mice
의약학 > 의공학
( Dae Seong Choi ) , ( Sok Ho Kim ) , ( Youn Mook Lim ) , ( Hui Jeong Gwon ) , ( Jong Seok Park ) , ( Young Chang Nho ) , ( Jung Kee Kwon )
조직공학과 재생의학 2012년, 제9권 제1호, 36~42페이지(총7페이지)
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    Proper wound management is an increasingly important clinical challenge and is a large and growing unmet need. Pressure ulcers, hard-to-heal wounds, and problematic surgical incisions are emerging with increasing frequency. At present, the wound-healing industry is experiencing a paradigm shift toward innovative treatments that exploit nanotechnology, biomaterials, and biologics. Here we determined the effectiveness of a radiation-processed hydrogel patch for the delivery of chestnut honey (CH) for the promotion of cutaneous wound healing in diabetic mice. CH is a natural compound that has antioxidant and bactericidal effects. Two full-thickness wounds were made on the dorsal side of diabetic (db/db) mice and the wounds were covered with hydrogel-incorporated CH. Time course observations revealed that mice treated with CH hydrogel showed accelerated wound closure and formation of granulated tissue, enhanced Ki-67 expression and early upregulated HO-1 proteins in the wound region compared with water hydrogel or non-treated mice. Taken together, these findings indicate that CH hydrogel can promote wound healing in diabetics with early HO-1 protein expression.
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